Article

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencing

2019-12-28

Abstract excerpt

Human induced pluripotent stem cells (iPSCs) offer the opportunity to generate specific cell types from healthy and diseased individuals, allowing the study of mechanisms of early human development, modelling a variety of human diseases, and facilitating the development of new therapeutics. Human iPSC-based applications are often limited by the variability among iPSC lines originating from a single donor, as well...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35a4b131-babb-5fd4-b569-35cd47b969b8
DOI: 10.1101/2019.12.28.889972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencingDOI 10.1101/2019.12.28.889972Read

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.Semantic proximity Read

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem CellsSemantic proximity Read

How to make spinal motor neuronsSemantic proximity Read

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factorsSemantic proximity Read

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neuronsSemantic proximity Read

Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectivesSemantic proximity Read

Single-nucleus transcriptomic atlas of spinal cord neuron in humanSemantic proximity Read

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac VectorsSemantic proximity Read

An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroidsSemantic proximity Read

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells.Semantic proximity Read

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cordSemantic proximity Read

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cellsSemantic proximity Read