Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes

19 Jul 2011

Abstract excerpt

Stem cell-derived motor neurons (MNs) are increasingly utilized for modeling disease in vitro and for developing cellular replacement strategies for spinal cord injury and diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Human embryonic stem cell (hESC) differentiation into MNs, which involves retinoic acid (RA) and activation of the sonic hedgehog (SHH) pathway is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Neurogenetic and Muscular Disorders Research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21772256
DOI: 10.1038/mt.2011.135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor CodesPMID 21772256Read ↗

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factorsSemantic proximity Read ↗

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem CellsSemantic proximity Read ↗

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neuronsSemantic proximity Read ↗

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.Semantic proximity Read ↗

Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus VectorsSemantic proximity Read ↗

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read ↗

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac VectorsSemantic proximity Read ↗

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor NeuronsSemantic proximity Read ↗

Global Transcriptome Profile of the Developmental Principles of in Vitro iPSC-to-Motor Neuron DifferentiationSemantic proximity Read ↗

Efficient generation of lower induced Motor Neurons by coupling <i>Ngn2</i> expression with developmental cuesSemantic proximity Read ↗

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells.Semantic proximity Read ↗

Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vectorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.