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Article

Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells.

Cell reports - 21 Jan 2020

Nickolls Alec R, Lee Michelle M, Espinoza David F, Szczot Marcin, Lam Ruby M, Wang Qi, Beers Jeanette, Zou Jizhong, Nguyen Minh Q, Solinski Hans J, AlJanahi Aisha A, Johnson Kory R, Ward Michael E, Chesler Alexander T, Bönnemann Carsten G

Abstract excerpt

Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally programmed to differentiate into a surprisingly uniform culture of cold- and mechano-sensing neurons. Although such a neuronal subtype is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31968264
DOI: 10.1016/j.celrep.2019.12.062
PMCID: PMC7059559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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