Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How genetic defects in piRNA trimming contribute to male infertility.

Andrology - 1 Jul 2023

Mann Jeffrey M, Wei Chao, Chen Chen

Abstract excerpt

In germ cells, small non-coding PIWI-interacting RNAs (piRNAs) work to silence harmful transposons to maintain genomic stability and regulate gene expression to ensure fertility. However, these piRNAs must undergo a series of steps during biogenesis to be properly loaded onto PIWI proteins and reach the correct nucleotide length. This review is focused on what we are learning about a crucial step in this process,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infertility, Male
Share to Mammals
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteins

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 36263612
DOI: 10.1111/andr.13324
PMCID: PMC10115909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How genetic defects in piRNA trimming contribute to male infertility.PMID 36263612Read ↗

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in miceSemantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

Variant PNLDC1, Defective piRNA Processing, and Azoospermia.Semantic proximity Read ↗

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis.Semantic proximity Read ↗

PIWI proteins and PIWI-interacting RNAs in the soma.Semantic proximity Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

Pachytene piRNAs define a conserved program of meiotic gene regulationSemantic proximity Read ↗

<i>yama</i> , a mutant allele of <i>Mov10l1</i> , disrupts retrotransposon silencing and piRNA biogenesisSemantic proximity Read ↗

Pachytene piRNAs define a conserved program of meiotic gene regulationSemantic proximity Read ↗

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.