Article

Transcriptomic analysis of loss of Gli1 in neural stem cells responding to demyelination in the mouse brain

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> In the adult mammalian brain, Gli1 expressing neural stem cells reside in the subventricular zone and their progeny are recruited to sites of demyelination in the white matter where they generate new oligodendrocytes, the myelin forming cells. Remarkably, genetic loss or pharmacologic inhibition of Gli1 enhances the efficacy of remyelination by these neural stem cells. To understand the molecula...

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Literature Corpus work: 913dd0da-f444-5648-8d70-d496f6a8af2d
DOI: 10.1101/2021.02.28.433246

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