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Development of glial restricted human neural stem cells for oligodendrocyte differentiation in vitro and in vivo

21 Jun 2019

Abstract excerpt

In this study, we have developed highly expandable neural stem cells (NSCs) from HESCs and iPSCs that artificially express the oligodendrocyte (OL) specific transcription factor gene Zfp488. This is enough to restrict them to an exclusive oligodendrocyte progenitor cell (OPC) fate during differentiation in vitro and in vivo. During CNS development, Zfp488 is induced during the early stages of OL generation, and...

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PMID: 31227736
DOI: 10.1038/s41598-019-45247-3

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