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Article

Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development.

Journal of neurochemistry - 1 Mar 2021

Hashimoto Misuzu, Kumabe Ayako, Kim Jun-Dal, Murata Kazuya, Sekizar Sowmya, Williams Anna, Lu Weizhe, Ishida Junji, Nakagawa Tsutomu, Endo Mitsuharu, Minami Yasuhiro, Fukamizu Akiyoshi

Abstract excerpt

PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell-specific PRMT1 conditional knockout (PRMT1-CKO) mice, the context of other glial cell states that may cause the hypomyelination...

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Identifiers

PMID: 33460120
DOI: 10.1111/jnc.15149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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