Article

Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer

2025-03-07

Abstract excerpt

<h4>Background</h4> Tumour budding (TB), defined as a small cluster of up to four cells at the invasive front of the tumour, is a well-established independent and robust prognostic biomarker in colorectal cancer (CRC). This is strongly associated with adverse clinicopathological features and poor survival outcomes. Despite its clinical relevance, the precise underlying mechanism responsible for TB phenomenon rema...

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Literature Corpus work: 91323ee9-e33d-552a-be41-c02ced7311e4
DOI: 10.1101/2025.03.05.641608

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