Article
Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching.
British journal of cancer - 3 Jan 2017
De Smedt Linde, Palmans Sofie, Andel Daan, Govaere Olivier, Boeckx Bram, Smeets Dominiek, Galle Eva, Wouters Jasper, Barras David, Suffiotti Madeleine, Dekervel Jeroen, Tousseyn Thomas, De Hertogh Gert, Prenen Hans, Tejpar Sabine, Lambrechts Diether, Sagaert Xavier
Abstract excerpt
BACKGROUND: Tumour budding, described as the presence of single cells or small clusters of up to five tumour cells at the invasive margin, is established as a prognostic marker in colorectal carcinoma. In the present study, we aimed to investigate the molecular signature of tumour budding cells and the corresponding tumour bulk. METHODS: Tumour bulk and budding areas were microdissected and processed for...
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