Article

Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRC

2021-08-31

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) ranks second for mortality and third for morbidity among the most commonly diagnosed cancers worldwide. Tumor microenvironment (TME) has been reported to correlate with CRC outcomes and treatment efficacy. Single-cell RNA sequencing (scRNA-seq) is an indispensable tool for unravelling cellular heterogeneity and deconstructing tissues into cell types, offering enormous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63e5d8b9-42ec-5fae-81ef-9f0aee7269de
DOI: 10.21203/rs.3.rs-836574/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRCDOI 10.21203/rs.3.rs-836574/v1Read

Single-cell transcriptome analysis reveals heterogeneity and convergence of the tumor microenvironment in colorectal cancerSemantic proximity Read

Intratumoral Heterogeneity of CRC Revealed by Single-Cell Transcriptome Analysis, which Results in Poor Prognosis Clinical OutcomesSemantic proximity Read

Landscape of Cell Heterogeneity and Evolutionary Trajectory in Ulcerative Colitis-associated Colon Cancer Revealed by Single-cell Rna SequencingSemantic proximity Read

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity Read

Dissection and reconstruction of the colorectal cancer tumor microenvironmentSemantic proximity Read

Integrated single-cell RNA-seq analysis identifies immune heterogeneity associated with KRAS/TP53 mutation status and tumor-sideness in colorectal cancers.Semantic proximity Read

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysisSemantic proximity Read

Single-cell transcriptional profiling reveals the heterogenicity in colorectal cancerSemantic proximity Read

Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancerSemantic proximity Read

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor MicroenvironmentsSemantic proximity Read

Redefining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read

Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancerSemantic proximity Read