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Integrated Single‐Cell RNA ‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer

1 Sept 2025

Abstract excerpt

ABSTRACT Background Colorectal cancer (CRC) remains a major challenge in oncology, necessitating the identification of new therapeutic targets. This study aimed to explore the CRC microenvironment and uncover potential targets using single‐cell RNA sequencing (scRNA‐seq). Methods Single‐cell RNA sequencing data from GEO (GSE164522, GSE132465, and GSE144735) were integrated and stratified based on CRC clinical...

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PMID: 40891683
DOI: 10.1002/cam4.71202

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