Article

Autism-Related Cc2d1a Heterozygous Mice: Increased Levels of miRNAs Retained in DNA/RNA Hybrid Profiles (R-loop)

2024-07-11

Abstract excerpt

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with a highly variable expression of phenotypes (restricted interest or activity and repetitive behavior in communication and social interactions), genes (mutation), markers (alteration of transcription) and pathways. Loss of function of the CC2D1A gene appears to primarily affect the brain, leading to a range of behavioral problems in humans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91305309-91e2-5466-8083-000d75663d23
DOI: 10.20944/preprints202407.0900.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autism-Related Cc2d1a Heterozygous Mice: Increased Levels of miRNAs Retained in DNA/RNA Hybrid Profiles (R-loop)DOI 10.20944/preprints202407.0900.v1Read

Analysis of RNA/DNA Hybrid Profiles in Blood From Autistic Patients Reveals Differences in mRNA and non-coding RNA RegionsSemantic proximity Read

An X-linked long non-coding RNA, PTCHD1-AS, regulates autistic behaviors in humans and in miceSemantic proximity Read

Experimentally altering microRNA levels in embryos alters adult phenotypes.Semantic proximity Read

CHD8 haploinsufficiency results in autistic-like phenotypes in mice.Semantic proximity Read

An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.Semantic proximity Read

Changes in social behaviour with alterations of MAPK3 and KCTD13/CUL3 pathways in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disordersSemantic proximity Read

Gene–environment interaction in neurodevelopmental disorders: Setd5 haploinsufficiency and prenatal carbon nanoparticle exposure synergistically induce ASD-like phenotypes in male miceSemantic proximity Read

Experimental alteration of the microRNA profile of the mouse embryo: heritable phenotypes in the adultSemantic proximity Read

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticitySemantic proximity Read

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.Semantic proximity Read

Germline Chd8 haploinsufficiency alters brain development in mouse.Semantic proximity Read

Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus.Semantic proximity Read