Article

Experimental alteration of the microRNA profile of the mouse embryo: heritable phenotypes in the adult

2023-02-21

Abstract excerpt

We previously identified a unique genetic feature of Autism Spectrum Disorder (ASD) in human patients and established mouse models, namely the low to very low level of six microRNAs, miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p and miR-499a-5p. We attempted to interfere experimentally with the expression in the mouse of two of them, miR19a-3p and miR499a-5p by microinjecting into the one-cell embryo...

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Literature Corpus work: cd53de29-fbd4-599f-9ba8-3f13f687c75d
DOI: 10.1101/2023.02.21.529218

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