Article

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity

2023-03-02

Abstract excerpt

<title>Abstract</title> <p>The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex in animals that can alter the topology of both DNA and RNA. <italic>TOP3B</italic> mutations in humans are associated with schizophrenia, autism and cognitive disorders; and <italic>Top3b</italic>-null mice exhibit several phenotypes observed in animal models...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17428ec7-a58d-5053-883f-8e2024ef420d
DOI: 10.21203/rs.3.rs-2597043/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticityDOI 10.21203/rs.3.rs-2597043/v1Read

Functional analysis of pathological mutations in DNA topoisomerase 3ASemantic proximity Read

Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunctionSemantic proximity Read

<i>Pgbd5</i> impacts neuronal differentiation and double strand breaks signaling in the developing cortexSemantic proximity Read

Dysfunction of a SET3-like complex underlies a family of related neurological disordersSemantic proximity Read

Developmental and behavioral phenotypes in a new mouse model of DDX3X syndromeSemantic proximity Read

A dual-activity topoisomerase complex regulates translation and abundance of mRNAs important for psychiatric disordersSemantic proximity Read

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.Semantic proximity Read

A Upf3b-mutant mouse model with behavioral and neurogenesis defects.Semantic proximity Read

Divergent phenotypes in germline versus conditional mutant mouse models of Sifrim-Hitz-Weiss SyndromeSemantic proximity Read

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disabilitySemantic proximity Read

Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse modelsSemantic proximity Read

Characterization of CTNND2-related neurodevelopmental disease, phenotype-genotype spectrum and WNT dynamics in early neurogenesisSemantic proximity Read