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Article

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.

Nature genetics - 1 Jun 2008

Stark Kimberly L, Xu Bin, Bagchi Anindya, Lai Wen-Sung, Liu Hui, Hsu Ruby, Wan Xiang, Pavlidis Paul, Mills Alea A, Karayiorgou Maria, Gogos Joseph A

Abstract excerpt

Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at high risk of developing schizophrenia. We analyzed an engineered mouse strain carrying a chromosomal deficiency spanning a segment syntenic to the human 22q11.2 locus. We uncovered a previously unknown alteration in the biogenesis of microRNAs (miRNAs) and identified a subset of brain miRNAs affected by the microdeletion. We...

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Source

Identifiers

PMID: 18469815
DOI: 10.1038/ng.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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