Single-cell multiome profiling reveals neuronal bias of modulatory role of MeCP2 phosphorylation.

Abstract excerpt

MeCP2 is subject to many post-translational modifications, such as phosphorylation, in response to diverse stimuli. Several MeCP2 phosphorylation sites have been identified and studied individually. However, the combinatorial effect of phosphorylation at multiple sites has not been directly examined. Building on previous studies characterizing single mutations of MeCP2 phosphorylation sites, we created a mouse...

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• Methyl-CpG-Binding Protein 2
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Multiomics