Article

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

2024-12-15

Abstract excerpt

Aberrant aggregation of the prion-like, RNA-binding protein TDP-43 underlies several debilitating neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). Here, we define how short, specific RNAs antagonize TDP-43 aggregation. Short, specific RNAs engage and stabilize the TDP-43 RNA-recognition motifs, which allosterically destabilizes a conserved helical region in the prion-like domain, t...

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Literature Corpus work: 40b15ece-3973-5c85-b518-f74f71b75aa6
DOI: 10.1101/2024.12.14.628507

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