Article
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
Cell - 2 Sept 2021
Hallegger Martina, Chakrabarti Anob M, Lee Flora C Y, Lee Bo Lim, Amalietti Aram G, Odeh Hana M, Copley Katie E, Rubien Jack D, Portz Bede, Kuret Klara, Huppertz Ina, Rau Frédérique, Patani Rickie, Fawzi Nicolas L, Shorter James, Luscombe Nicholas M, Ule Jernej
Abstract excerpt
Mutations causing amyotrophic lateral sclerosis (ALS) often affect the condensation properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the specificity and function of protein-RNA complexes remains unclear. We created a series of TDP-43 C-terminal domain (CTD) variants that exhibited a gradient of low to high condensation propensity, as observed in vitro and by nuclear mobility and...
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