Article
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2020
Vaubel Rachael A, Tian Shulan, Remonde Dioval, Schroeder Mark A, Mladek Ann C, Kitange Gaspar J, Caron Alissa, Kollmeyer Thomas M, Grove Rebecca, Peng Sen, Carlson Brett L, Ma Daniel J, Sarkar Gobinda, Evers Lisa, Decker Paul A, Yan Huihuang, Dhruv Harshil D, Berens Michael E, Wang Qianghu, Marin Bianca M, Klee Eric W, Califano Andrea, LaChance Daniel H, Eckel-Passow Jeanette E, Verhaak Roel G, Sulman Erik P, Burns Terry C, Meyer Fredrick B, O'Neill Brian P, Tran Nhan L, Giannini Caterina, Jenkins Robert B, Parney Ian F, Sarkaria Jann N
Abstract excerpt
PURPOSE: Glioblastoma is the most frequent and lethal primary brain tumor. Development of novel therapies relies on the availability of relevant preclinical models. We have established a panel of 96 glioblastoma patient-derived xenografts (PDX) and undertaken its genomic and phenotypic characterization. EXPERIMENTAL DESIGN: PDXs were established from glioblastoma, IDH-wildtype (n = 93), glioblastoma, IDH-mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.