Article

Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures

2025-08-01

Abstract excerpt

<h4>Summary/Abstract</h4> Glioblastoma stem cell (GSC) cultures are initiated from glioblastoma (GBM) surgical resection tissue. They can capture and propagate key GBM primary tumor molecular and cellular features. We have deeply characterized four isocitrate dehydrogenase (IDH)-expressing (or IDH+) GSC cultures from unrelated adults to serve as cellular models for the majority of adult primary GBM. We demonstrat...

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Literature Corpus work: 279f6721-9e7b-5bbc-be24-bc99f538d2ad
DOI: 10.1101/2025.07.29.667532

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