Back to search

Article

Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients.

2022-01-01

Abstract excerpt

Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells. We purified and characterized tumor-infiltrating lymphocytes (TILs) and their patient-matched non-tumor counterparts from treatment-naïve NSCLC patient biopsies to evaluate the effect of PD1 expression on the functional and molecular profiles of tumor-resident...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
91011f5d-ea93-5654-8c09-2f236c66b7ed
DOI
10.48350/165815
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients.DOI 10.48350/165815
Functional and Molecular Characterization of PD1+ Tumor-Infiltrating Lymphocytes From Lung Cancer PatientsSemantic proximity
Lung tumor-infiltrating T <sub>reg</sub> have divergent transcriptional profiles and function linked to checkpoint blockade responseSemantic proximity
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancerSemantic proximity
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.Semantic proximity
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumorsSemantic proximity
IRF4 instructs effector Treg differentiation and immune suppression in human cancerSemantic proximity
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.Semantic proximity
Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profileSemantic proximity
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigensSemantic proximity
Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockadeSemantic proximity
The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.Semantic proximity
Low PD-1 Expression in Cytotoxic CD8+ Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value.Semantic proximity
Select a neighboring publication to make it the new centre.