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Article

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.

Nature communications - 10 Aug 2018

Gettinger S N, Choi J, Mani N, Sanmamed M F, Datar I, Sowell Ryan, Du Victor Y, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm D L, Chen L, Herbst R S, Schalper K A

Abstract excerpt

The biological determinants of sensitivity and resistance to immune checkpoint blockers are not completely understood. To elucidate the role of intratumoral T-cells and their association with the tumor genomic landscape, we perform paired whole exome DNA sequencing and multiplexed quantitative immunofluorescence (QIF) in pre-treatment samples from non-small cell lung carcinoma (NSCLC) patients treated with PD-1...

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Source

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Identifiers

PMID: 30097571
DOI: 10.1038/s41467-018-05032-8
PMCID: PMC6086912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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