Low PD-1 Expression in Cytotoxic CD8+ Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value.

doi:10.1158/1078-0432.CCR-17-2156

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Article

Low PD-1 Expression in Cytotoxic CD8+ Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Mazzaschi Giulia, Madeddu Denise, Falco Angela, Bocchialini Giovanni, Goldoni Matteo, Sogni Francesco, Armani Giovanna, Lagrasta Costanza Annamaria, Lorusso Bruno, Mangiaracina Chiara, Vilella Rocchina, Frati Caterina, Alfieri Roberta, Ampollini Luca, Veneziani Michele, Silini Enrico Maria, Ardizzoni Andrea, Urbanek Konrad, Aversa Franco, Quaini Federico, Tiseo Marcello

Abstract excerpt

Purpose: The success of immune checkpoint inhibitors strengthens the notion that tumor growth and regression are immune regulated. To determine whether distinct tissue immune microenvironments differentially affect clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis of PD-L1 and tumor-infiltrating lymphocytes (TIL) was performed.Experimental Design: Samples from resected adenocarcinoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29074606
DOI: 10.1158/1078-0432.CCR-17-2156

Genes

EGFR
FOXP3
KRAS

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