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Article

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

21 Jun 2019

Abstract excerpt

High numbers of tissue-resident memory T (TRM) cells are associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, single-cell and bulk transcriptomic analysis of TRM and non-TRM cells present in tumor and normal lung tissue from patients with lung cancer revealed that PD-1–expressing TRM...

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PMID: 31227543
DOI: 10.1084/jem.20190249

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