A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.

doi:10.1038/s41591-018-0057-z

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Article

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.

Nature medicine - 1 Jul 2018

Thommen Daniela S, Koelzer Viktor H, Herzig Petra, Roller Andreas, Trefny Marcel, Dimeloe Sarah, Kiialainen Anna, Hanhart Jonathan, Schill Catherine, Hess Christoph, Savic Prince Spasenija, Wiese Mark, Lardinois Didier, Ho Ping-Chih, Klein Christian, Karanikas Vaios, Mertz Kirsten D, Schumacher Ton N, Zippelius Alfred

Abstract excerpt

Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels. We compared transcriptional, metabolic...

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PMID: 29892065
DOI: 10.1038/s41591-018-0057-z
PMCID: PMC6110381

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CXCL13

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