Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cells

Abstract excerpt

The Rho GTPase family is involved in actin dynamics and regulates the barrier function of the endothelium. One of the main barrier-promoting Rho GTPases is Cdc42, also known as cell division control protein 42 homolog. Currently, regulation of Cdc42-based signaling networks in endothelial cells (ECs) lack molecular details. To examine these, we focused on a subset of 15 Rho guanine nucleotide exchange factors (GEF...

Topics

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• cdc42 GTP-Binding Protein
• Endothelin-1
• Endothelins
• MAP Kinase Kinase 4
• rac1 GTP-Binding Protein
• Receptor, Endothelin A
• Receptors, Endothelin
• rhoA GTP-Binding Protein

Identifiers and source

Literature Corpus work

90f4a1d8-2251-58ac-a3a8-d68a6000a26c

DOI

10.1101/541219