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Article

Double inhibition and activation mechanisms of Ephexin family RhoGEFs.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2021

Zhang Meng, Lin Lin, Wang Chao, Zhu Jinwei

Abstract excerpt

Ephexin family guanine nucleotide exchange factors (GEFs) transfer signals from Eph tyrosine kinase receptors to Rho GTPases, which play critical roles in diverse cellular processes, as well as cancers and brain disorders. Here, we elucidate the molecular basis underlying inhibition and activation of Ephexin family RhoGEFs. The crystal structures of partially and fully autoinhibited Ephexin4 reveal that the...

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Identifiers

PMID: 33597305
DOI: 10.1073/pnas.2024465118
PMCID: PMC7923574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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