Article
WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
Biochemical and biophysical research communications - 19 Nov 2004
Wang Yuhui, Suzuki Hiroaki, Yokoo Tomotaka, Tada-Iida Kaoruko, Kihara Rumi, Miura Mitsuhiro, Watanabe Kazuhisa, Sone Hirohito, Shimano Hitoshi, Toyoshima Hideo, Yamada Nobuhiro
Abstract excerpt
Rho family GTPases regulate multiple cellular processes through their downstream effectors, where their activities are stimulated by the guanine nucleotide exchange factors. Here, we report a new member of RhoGEF, WGEF, which has the classical structure of DH-PH domain and a C-terminal SH3 domain. WGEF was shown to activate RhoA, Cdc42, and Rac1 by pulldown assay, and forced expression of WGEF resulted in marked...
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