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Article

Rho family GTPases.

Biochemical Society transactions - 1 Dec 2012

Hall Alan

Abstract excerpt

Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide range of other...

Topics

Actin Cytoskeleton
Animals
Cell Movement
Cell Shape
Humans
Mutation
Neoplasms
Signal Transduction
rho GTP-Binding Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23176484
DOI: 10.1042/BST20120103

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