Article
Many faces of Ras activation.
Biochimica et biophysica acta - 1 Dec 2008
Buday László, Downward Julian
Abstract excerpt
Ras proteins were originally identified as the products of oncogenes capable of inducing cell transformation. Over the last twenty-five years they have been studied in great detail because mutant Ras proteins are associated with many types of human cancer. Wild type Ras proteins play a central role in the regulation of proliferation and differentiation of various cell types. They alternate between an active...
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