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Article

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.

The Journal of biological chemistry - 19 Nov 1999

Reid T, Bathoorn A, Ahmadian M R, Collard J G

Abstract excerpt

Guanine nucleotide exchange factors of the Dbl family regulate the actin cytoskeleton through activation of Rho-like GTPases. At present the Dbl family consists of more than thirty members; many have not been phenotypically or biochemically characterized. Guanine nucleotide exchange factors universally feature a Dbl homology domain followed by a pleckstrin homology domain. Employing data base screening we...

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PMID: 10559246
DOI: 10.1074/jbc.274.47.33587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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