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RhoGTPase in Vascular Disease

6 Jun 2019

Abstract excerpt

Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Given its role in many physiological and pathological functions, targeting can result in adverse effects and limit its use for therapy....

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PMID: 31174369
DOI: 10.3390/cells8060551

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