Article
Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling.
The Biochemical journal - 5 Aug 2026
Wajed Shah, Ferrandez Yann, Zeghouf Mahel, Ghasemi Rasta, Puertas Cylia, Nawrotek Agata, Gesbert Franck
Abstract excerpt
Small GTPases of the Ras superfamily act as molecular switches cycling between GDP-bound inactive and GTP-bound active states. Their signaling output depends not only on GTP loading but on continuous nucleotide cycling controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). While Glycine 12 substitutions in Ras typically confer constitutive activation, the effects of...
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