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Combining local cryoablation with PD-L1 blockade synergistically eradicates established murine lung cancer by modulating mitochondrial in PD-1+CD8+ T cell

2023-02-09

Abstract excerpt

Immune checkpoint blockade (ICB) has shown improvement in overall survival for lung cancer in clinical trials. However, monotherapies have limited efficacy in improving outcomes and benefit only a subset of patients. Combination therapies targeting multiple pathways can augment an immune response to improve survival further. Here, we demonstrate that combinatorial anti-PD-L1/cryoablation therapy generated a synerg...

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Literature Corpus work
90b488bf-a09c-5532-a6c4-b418604c8b69
DOI
10.21203/rs.3.rs-2558286/v1
Open publication

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Combining local cryoablation with PD-L1 blockade synergistically eradicates established murine lung cancer by modulating mitochondrial in PD-1+CD8+ T cellDOI 10.21203/rs.3.rs-2558286/v1
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