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Article

EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment.

Oncotarget - 19 Jan 2016

Zhang Hongjuan, Zhan Cheng, Ke Ji, Xue Zhiqiang, Zhang Aiqun, Xu Kaifeng, Shen Zhirong, Yu Lei, Chen Liang

Abstract excerpt

Lung cancer is the global leading cause of cancer-related deaths. A significant portion of lung cancer patients harbor kinase domain mutations in the epidermal growth factor receptor (EGFR). While EGFR tyrosine kinase inhibitors (TKI) effectively shrink tumors harboring mutant EGFR, clinical efficacy is limited by the development of TKI resistance. Effective alternatives are desperately needed in clinic for...

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Identifiers

PMID: 26654941
DOI: 10.18632/oncotarget.6491
PMCID: PMC4823112

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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