Article

Nanosecond laser-driven proton FLASH spares normal tissue cells by sustaining mitochondrial homeostasis and attenuating ferroptosis

2026-03-16

Abstract excerpt

Radiotherapy’s clinical utility remains fundamentally constrained by the collateral damage to healthy tissues. Ultra-high-dose-rate (UHDR) irradiation, or, FLASH-radiotherapy (FLASH-RT) has emerged as a transformative paradigm to mitigate such toxicity. However, the biological effects of FLASH-RT on the high-efficiency of tumor killing and normal tissue sparing remain poorly understood. In this work, we utilized a...

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Literature Corpus work: 2d298308-c2de-5cbc-8bc5-62cfa9e989b8
DOI: 10.64898/2026.03.13.711531

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