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Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming

25 Mar 2020

Abstract excerpt

Radiotherapy (RT) is routinely used in cancer treatment, but expansion of its clinical indications remains challenging. The mechanism underlying the radiation-induced bystander effect (RIBE) is not understood and not therapeutically exploited. We suggest that the RIBE is predominantly mediated by irradiated tumor cell-released microparticles (RT-MPs), which induce broad antitumor effects and cause immunogenic...

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PMID: 32232155
DOI: 10.1126/sciadv.aay9789

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