Article

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

2025-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Trametinib (Trm) is a highly selective MEK inhibitor that potently and persistently abrogates ERK1/2 activation. Trm initially was used to treat BRAF V600E-mutated melanoma but its FDA-approved indications are expanding rapidly. Trm generally is well tolerated but it can cause dose-limiting cardiomyopathy and heart failure. Here we characterize a mouse model of Trm cardiotoxicity using complemen...

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Literature Corpus work: 5036a390-22aa-50cb-b841-fd6729cab95d
DOI: 10.1101/2025.09.05.671511

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