Article

Polygenic Risk Scores Provide Strong Evidence for the Biologic Relevance of Molecular Subtypes of Schizophrenia

2024-06-22

Abstract excerpt

We have previously described how the DLPFC transcriptomes of schizophrenia patients can be used to define two patient groups: “Type 1” patients with a relatively normal DLPFC transcriptome and “Type 2” patients with hundreds of genes differentially expressed in the DLPFC at a statistical significance which survives Bonferroni correction. The biological significance of the distinction between Type 1 and Type 2 pati...

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Literature Corpus work: 909e45b3-ee30-5bcf-a3ad-adce89ebaa24
DOI: 10.1101/2024.06.21.24309320

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