Article
Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2023
Duncan Laramie, Shen Hanyang, Schulmann Anton, Li Tayden, Kolachana Bhaskar, Mandal Ajeet, Feng Ningping, Auluck Pavan, Marenco Stefano
Abstract excerpt
A new era of human postmortem tissue research has emerged thanks to the development of 'omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is the ability to construct polygenic scores, individual-level metrics of genetic risk (also known as polygenic risk scores/PRS), based on genome-wide association studies, GWAS. Here, we report on clinical,...
Topics
- Humans
- Genome-Wide Association Study
- Schizophrenia
- Bipolar Disorder
- Multifactorial Inheritance
- Brain
- Genetic Predisposition to Disease