Article
Biological insights into schizophrenia from ancestrally diverse populations.
Nature - 1 Mar 2026
Bigdeli Tim B, Chatzinakos Chris, Bendl Jaroslav, Barr Peter B, Venkatesh Sanan, Gorman Bryan R, Clarence Tereza, Genovese Giulio, Iyegbe Conrad O, Peterson Roseann E, Kolokotronis Sergios-Orestis, Burstein David, Meyers Jacquelyn L, Li Yuli, Natarajan Sundar, Francis Michael O, Rajeevan Nallakkandi, Cheung Kei-Hoi, DeLisi Lynn E, Kosten Thomas R, Zhao Hongyu, Achtyes Eric, Buckley Peter F, Malaspina Dolores, Lehrer Douglas, Rapaport Mark H, Braff David L, Pato Michele T, Fanous Ayman H, Pato Carlos N, Huang Grant D, Muralidhar Sumitra, Gaziano J Michael, Pyarajan Saiju, Girdhar Kiran, Lee Donghoon, Hoffman Gabriel E, Aslan Mihaela, Fullard John F, Voloudakis Georgios, Harvey Philip D, Roussos Panos
Abstract excerpt
Schizophrenia and related psychoses occur in all human populations, with the highest rates of diagnosis among Black individuals and those of mainly African ancestry1. Decades of research have established a highly heritable and polygenic basis for schizophrenia, which is mostly shared across populations2-4. However, a recruitment bias towards European cohorts5 has led to discoveries that are poorly generalizable...
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