Article

Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington disease

2022-12-06

Abstract excerpt

Astroglial dysfunction contributes to the pathogenesis of Huntington’s disease (HD), and glial replacement can ameliorate disease course. To establish the topographic relationship of diseased astrocytes to medium spiny neuron (MSN) synapses in HD, we used 2-photon imaging to map the relationship of tRFP-tagged striatal astrocytes and rabies-traced, EGFP-tagged coupled neuronal pairs, in R6/2 HD and wild-type (WT)...

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Literature Corpus work: 75d51d3c-0c76-5cf3-bf46-0fe6e79bfd7d
DOI: 10.1101/2022.12.06.519168

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