Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

Abstract excerpt

<h4>ABSTRACT</h4> <h4>OBJECTIVE</h4> A key event in atherogenesis is the formation of lipid-loaded macrophages, lipidotic cells, which exhibit irreversible accumulation of undigested modified low-density lipoproteins in lysosomes. This event culminates with the loss of cell homeostasis, inflammation and cell death. In this study we propose to identify the chemical etiological factors and understanding the molecu...

Topics

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• Autophagosomes
• Autophagy
• Autophagy in Disease and Therapy
• Cholesterol and Lipid Metabolism
• Disease Management
• Genetic Therapy
• Lipid metabolism and biosynthesis
• Lysosomes

Identifiers and source

Literature Corpus work

25a5dbad-be8b-5ad4-b5ac-e064e324860e

DOI

10.1101/2021.01.05.422575