Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.

doi:10.1172/JCI95612

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Article

Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.

The Journal of clinical investigation - 1 Feb 2018

Chang Che-Feng, Goods Brittany A, Askenase Michael H, Hammond Matthew D, Renfroe Stephen C, Steinschneider Arthur F, Landreneau Margaret J, Ai Youxi, Beatty Hannah E, da Costa Luís Henrique Angenendt, Mack Matthias, Sheth Kevin N, Greer David M, Huttner Anita, Coman Daniel, Hyder Fahmeed, Ghosh Sourav, Rothlin Carla V, Love J Christopher, Sansing Lauren H

Abstract excerpt

Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute to recovery after acute sterile brain injury. By profiling the transcriptional dynamics of MDMs in the murine brain after experimental intracerebral hemorrhage (ICH), we found robust phenotypic...

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PMID: 29251628
DOI: 10.1172/JCI95612
PMCID: PMC5785262

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