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Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis

16 Jun 2004

Abstract excerpt

Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the ATF/CREB family of transcription factors. However, the physiological significance of ATF3 induction by stress signals is not clear. In this report, we describe several lines of evidence supporting a role of ATF3 in stress-induced beta-cell apoptosis. First, ATF3 is induced in beta cells by signals relevant to beta-cell...

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PMID: 15199129
DOI: 10.1128/mcb.24.13.5721-5732.2004

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