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Article

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function.

Endocrinology - 1 Jan 2022

Hoang Monica, Jentz Emelien, Janssen Sarah M, Nasteska Daniela, Cuozzo Federica, Hodson David J, Tupling A Russell, Fong Guo-Hua, Joseph Jamie W

Abstract excerpt

Pancreatic β-cells can secrete insulin via 2 pathways characterized as KATP channel -dependent and -independent. The KATP channel-independent pathway is characterized by a rise in several potential metabolic signaling molecules, including the NADPH/NADP+ ratio and α-ketoglutarate (αKG). Prolyl hydroxylases (PHDs), which belong to the αKG-dependent dioxygenase superfamily, are known to regulate the stability of...

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PMID: 34718519
DOI: 10.1210/endocr/bqab226
PMCID: PMC8643417

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