Article

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and function

2019-09-18

Abstract excerpt

<h4>Summary</h4> Although stress response maintains cell function and survival under adverse conditions, over-activation of late-stage stress-gene effectors causes dysfunction and death. Here we show that the Myelin Transcription Factors (Myt 1, 2, and 3 TFs) prevent this over-activation. Co-inactivating Myt TFs in mouse pancreatic progenitors compromised postnatal β-cell function, proliferation, and survival, p...

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Literature Corpus work: 8eb42b69-2988-5b16-804e-94b7ec672404
DOI: 10.1101/773846

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