Article

Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis

2024-03-19

Abstract excerpt

Long-lived PFKFB3 expressing β-cells are dysfunctional cells because of prevailing glycolysis that compromises metabolic coupling of insulin secretion. Their accumulation in type-2 diabetes (T2D) appears to be related to the loss of apoptotic competency of cell fitness competition (CFC) that maintains tissue function by favoring constant selection of healthy “winner” cells. To investigate how PFKFB3 can disguise t...

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Literature Corpus work: c3fca449-3961-575b-a9de-19071d94b55d
DOI: 10.1101/2024.03.18.585508

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