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Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretion

2020-04-24

Abstract excerpt

<h4>Aims/hypothesis</h4> Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic beta cells. Whether mitochondrial networks may be important for glucose or incretin sensing has yet to be determined. <h4>Methods</h4> Here, we generated mice with beta cell-selective, adult-restricted deletion of the mitofusin genes Mfn1 and Mfn2 (β Mfn1/2 dKO). Whole or dissociated pancreati...

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Literature Corpus work
19bb0293-915d-5f8b-8214-c00e40ec92d7
DOI
10.1101/2020.04.22.055384
Open publication

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Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionDOI 10.1101/2020.04.22.055384
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