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Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues

2024-07-07

Abstract excerpt

Immune cells infiltrate tissues in response to exogenous pathogens or spontaneous tumors, generating protective immunity to safeguard tissues. Despite advancements in spatial transcriptomics (ST), the precise spatial distribution and functional specialization of immune cells within tissue microenvironments remain elusive. Here, we introduce an ultra-precision ST deconvolution algorithm (UCASpatial) that enhances t...

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Literature Corpus work
8a08db92-768c-5210-9a57-893ab208cf52
DOI
10.1101/2024.07.05.602200
Open publication

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Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissuesDOI 10.1101/2024.07.05.602200
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